1. Pathogenesis and early intervention of cognitive dysfunction-related brain diseases, Alzheimer's disease, fragile X syndrome and depression;

2. Establishment of Hubei Memory & Aging Cohort Study (HMACS) and its advanced biobank (Registration Number: ChiCTR1800019164).

Early intervention and the pathogenic molecular mechanism of fragile X syndrome; the role of autophagy, mitophagy and immune system interactions in animal models of autism spectrum disorder.

1. starting from "reward and emotional memory", using neural loop research methods (such as photogenetics, chemical genetics, in vivo electrophysiological recording and optical fiber recording, etc.) and molecular biology, to study the neural loop and molecular mechanism of drug addiction and anxiety.

2. Systematic preclinical evaluation of new drugs for drug addiction and anxiety disorders by means of behavioral pharmacology.